In our study, the plasma levels of sIL-6Ra [10,222.24 (4919.39–15,021.40) pg/mL] and gp130/sIL-6Rb [38,852.52 (24,600.59–53,741.86) pg/mL] were increased in obese patients without T2DM compared to obese patients with T2DM and controls (p < 0.05). The gene discussed is IL6ST; the disease is type 2 diabetes mellitus.