Other studies have reported that the Lachnospiraceae family is more abundant in AD preclinical models (3 month-old APP/ PS1 mice and 5xFAD mice at 6 months of age) [90,134] as well as in metabolic disease preclinical models (both after HFD administration and in 15-17 week old ob/ob mice) [203,206]. Here, APP is linked to Alzheimer disease.