Interestingly, IL1-β, IL-12p70 and IL-13 correlate with insulin levels in APP/PS1xdb/db mice and IL-3, IL-17, IL-4, and KC (CXCL1) are also affected in these mice [12], suggesting that specific cytokine profiles are associated with AD and T2DM. This evidence concerns the gene INS and type 2 diabetes mellitus.