AD and T2DM share common pathological features that include impairment in insulin signaling, alteration of amyloid and tau pathologies or vascular damage that have been largely revised before (Mejido, Penny et al., 2020; Goncalves et al., 2019; Ferreira et al., 2019; Vieira et al., 2018). Here, INS is linked to Alzheimer disease.