It is possible that STAT3 signaling could be activated downstream of the MAPK pathways in response to TLR7 activation, as already demonstrated in other contexts [57], and that it could be the main transcription factor responsible for the pro-resolving/anti-angiogenic response of NSCLC cells as already reported in GC [17]. The gene discussed is TLR7; the disease is non-small cell lung carcinoma.