STAT3 and non-small cell lung carcinoma: Here we demonstrate that (i) TLR7 expression and activation inversely correlated with the angiogenic potential in NSCLC cells and patients; (ii) TLR7 expression and activation directly correlated with pro-resolving pathway components’ expression in NSCLC cells and patients; (iii) the increased angiogenic potential of NSCLC cells silenced for TLR7 can be restored by the addition of SPMs; (iv) TLR7-mediated activation of MAPK and STAT3 signaling is responsible for its pro-resolving and anti-angiogenic properties.