To verify whether TLR7 silencing in NSCLC cells could modulate pro-resolving pathways, we correlated TLR7 expression to the levels of enzymes involved in pro-resolving mediator synthesis (i.e., ALOX5, ALOX15A, and ALOX15B), the release of pro-resolving mediators (i.e., RvD1 and LXB4), and of inflammatory autacoids (i.e., PGD2 and LTB4) [17,30], in parallel to the synthesis of vascular endothelial growth factor A (VEGF-A)—the main mediator of new vessel formation [21,27]. The gene discussed is ALOX15B; the disease is non-small cell lung carcinoma.