The zebrafish van gogh (vgo) mutant affects the transcription factor Tbx1, the loss of which presents both heart and craniofacial defects associated with human DiGeorge syndrome as hypothesized due to a perturbed Tbx1–Wnt regulatory axis in the CPF [139,140,186,209,210,211]. This evidence concerns the gene TBX1 and 22q11.2 deletion syndrome.