Further studies reinforced this finding: one showed that chronic stimulation of human islets with palmitate ex vivo leads to decreased GSIS, which is further exaggerated by FFAR1 stimulation with the selective FFAR1 partial allosteric agonist TAK-875, the first clinically exploited allosteric modulator of the entire FFAR family, and reduced by FFAR1 inhibition with ANT203 [38]; another study demonstrated the beneficial effects of treating type 2 diabetic db/db mice with the FFAR1 antagonist DC260126 in terms of hyperinsulinemia and insulin sensitivity [39]. This evidence concerns the gene INS and hyperinsulinism.