RUNX1 and acute myeloid leukemia: In addition, we have also included in the AML driver-gene list the six fusion proteins most commonly identified in AML patients: AML1-ETO, BCR-ABL, CBFbeta-MYH11, MLL-fusions and PML-RARalpha and those involving the NUP98 gene, as about 20% of AML patients show chromosomal translocations, which often cause gene fusions encoding onco-fusion proteins [18].