A relatively new system published by a European group in 2015 is the Helsinki score which relay on mitotic rate, necrosis and Ki-67 index (3× mitotic count [>5/50 high power fields] + 5× presence of necrosis + Ki-67 proliferative index in the most proliferative index of the tumour) of ACC and focus on the predicting diagnosis as well as prognosis of ACC [61,62]. The gene discussed is MKI67; the disease is neoplasm.