In adult patients with ACC, these syndromes include multiple endocrine neoplasia type 1 (MEN1, approximately 20 cases reported) [30], Lynch syndrome (mismatch repair genes) (approximately 10 cases) [31], Li-Fraumeni syndrome (TP53, more than 10 cases) [32] and neurofibromatosis type 1 (NF1, approximately 10 cases) [33]. The gene discussed is TP53; the disease is adrenal cortex carcinoma.