For the former four genes (TMEM45B, NANS, GPR110, and SRD5A3), we demonstrated upregulations of TMEM45B, NANS, and SRD5A3 in PC initiation and metastatic progression as well as significant increases of all four genes in LNCaP cell-derived CRPCs (Figure 3 and Figure 6). The gene discussed is SRD5A3; the disease is pachyonychia congenita.