In summary, although our study is limited to the toxicological roles of IS and its hepatic production enzyme SULT1A1 in cisplatin-induced AKI and has not explored the involvement of other harmful uremic toxins such as p-cresyl sulfate or trimethylamine-N-oxide, our data identified for the first time the toxicological and pathological roles of IS and SULT1A1 in cisplatin-induced AKI. This evidence concerns the gene SULT1A1 and acute kidney injury.