Gupta et al. performed a retrospective cohort study and a retrospective cross-sectional study using the data of the era before anti-TNF α treatment (1988 to 1997), and the results demonstrated that regardless of anti-TNF α use, patients with IBD were more likely to have a higher incidence of MS, demyelination and ON compared with a matched control. This evidence concerns the gene TNF and myeloid sarcoma.