Metformin suppressed the protein (Figure 3A,B) and mRNA (Figure 3C) expressions of euchromatic histone lysine methyltransferase 1, 2 (EHMT1, EHMT2), enhancer of zeste 1, 2 polycomb repressive complex 2 subunit (EZH1, EZH2), lysine methyltransferase 2A, 2B (MLL1, MLL2), and WD repeat domain 82 (WDR82) in lung cancer cells. This evidence concerns the gene KMT2B and lung cancer.