Moreover, in a meta-analysis of studies examining the diagnostic accuracy of CSF t-tau, p-tau, and Aβ42 in discriminating between frontotemporal lobar degeneration dementias and Alzheimer’s disease, the p-tau/Aβ42 ratio had the best distinguishing value, especially in more cognitive-impaired patients [129]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.