SNAP25 and early-onset autosomal dominant Alzheimer disease: In two recent studies worth noting, there were significantly higher levels of SNAP-25 and synaptotagmin-1 in patients with atypical Alzheimer’s disease compared to those with frontotemporal dementia [306], and patients with vascular dementia had lower CSF synaptophysin levels than their counterparts in the Alzheimer’s disease group [307].