Thus, we designed a polyepitope construct (ICEM, Table 1) by combining four well-known HLA-A*02:01 epitopes derived from three viral proteins (memory antigens: influenza M1, CMV pp65, and EBV BMLF1) and one tumour protein (naïve antigen: Melan-A) presenting a high basal precursor frequency in healthy donors. Here, MLANA is linked to neoplasm.