Numerous inflammatory mediators such as TNF-α, IL-6, IL-10, IL-23, and transforming growth factor-β (TGF-β) were found to be associated with carcinogenesis and the development of CRC and their effects include pro-tumor, anti-tumor, and double-edge effects in CRC pathogenesis [16,17]. This evidence concerns the gene TGFB1 and colorectal carcinoma.