Mutations in ARID1A (p = 0.0205), ARID2 (p = 0.0207), BRAF (p = 0.023) SMARCA4 (p = 0.015), TERT (p = 0.0041), and IDH1 (p = 0.0041) were significantly exclusive to BM while the same variants remained undetected in the corresponding extracranial tumor tissues. The gene discussed is IDH1; the disease is neoplasm.