In addition to ARID1A mutations, our data also indicated variants of unknown significance in other components of the SWI/SNF complex, such as ARID2 and SMARCA4. Single nucleotide modifications in ARID2 and SMARCA4, all of unknown function but together with mutated splice site and frameshifts events often summarized and reviewed as “loss-of-function mutations”, have already been reported in extracranial melanomas [13,50,51,52]. The gene discussed is ARID2; the disease is melanoma.