In summary, 11/54 (20%, Figure 2A) and 6 of the 11 patient-matched brain pairs (55%, Figure 2B) of our discovery samples harbored genetic modifications in a component of the SWI/SNF machinery, implicating a potential role for dysregulation of chromatin remodeling in promoting the formation of melanoma CNS metastases. The gene discussed is SMARCA1; the disease is melanoma.