In the multiple regression model, after adjusting for significant clinical variables, endostatin > quartile 3 was an independent predictor of mortality due to stroke (HR = 1.835, 95% CI = 1.196–2.815, p = 0.005), together with age (HR = 1.054, 95% CI = 1.029–1.079, p < 0.001), hypertension (HR = 1.626, 95% CI = 0.953–2.772, p = 0.074), and basal NIHSS (HR = 1.144, 95% CI = 1.110–1.178, p < 0.001). This evidence concerns the gene COL18A1 and hypertensive disorder.