Given that UFMylation has been associated with numerous biological processes, most notably ER stress and maintaining protein homeostasis [10], the UFM1 system is a potential key player in the pathogenesis and progression of numerous diseases ranging from diabetes to cancer, a range of inflammatory diseases, certain hepatitis types, and neurodevelopmental disorders [75,80,106,107,108,109,110,111,112,113]. The gene discussed is UFM1; the disease is cancer.