In contrast, in a different study using the mouse model of urokinase plasminogen activator-overexpressing mice fed a high fat diet, ablation of CD8+ cells promoted HCC development and IgA+ expressing plasma cells were seen as immune suppressing cells found in abundance in mice and NASH patients, expressing PD-L1 and IL-10 [217]. Here, CD8A is linked to metabolic dysfunction-associated steatohepatitis.