Mice overexpressing the transcriptional repressor unconventional prefoldin RPB5 interactor (URI) were fed a high fat diet; it was demonstrated that DNA damage triggered IL-17A release, which promoted neutrophil infiltration in adipose tissue, causing insulin resistance, steatohepatitis and HCC, which was prevented by blocking IL-17. The gene discussed is IL17A; the disease is hepatocellular carcinoma.