TM6SF2 and metabolic dysfunction-associated steatotic liver disease: Numerous single-nucleotide polymorphisms (SNPs) have been identified as genetic modifiers of NAFLD, with SNPs in the genes encoding PNPLA3 (platin-like phospholipase domain containing 3) and TM6SF2 (transmembrane 6 superfamily member 2) receiving the most attention [24].