IL6 and neoplasm: It was subsequently shown that a variety of tumor cells exposed to genotoxic chemotherapy or ionizing radiation, with or without PARP inhibition (including lung, breast and colon), can escape from an established senescence phenotype, and resume growth, accompanied by partial or complete resolution of SA-β-gal staining and decreased expression of CDKIs (e.g., p21Cip1) and SASP factors (e.g., IL-1, IL-6, IL-8) [26,48].