However, in contrast to the hoped-for improvement in the efficacy of chemotherapy coupled with senolytics, the induction of TIS, of itself, was reported to improve outcomes in a cyclophosphamide-treated BCL-2 lymphoma mouse model; it should be noted, though, that evidence for senescence induction was extrapolated indirectly based on the functional status of the INK4a locus in tumor cells [139]. The gene discussed is CDKN2A; the disease is neoplasm.