Figure 3a shows the percentages of up- and down-regulated genes of each pathway compared with MRL/+, and Figure 3b displays the weighted pathway regulation (WPR) differences among the 3 phenotypes for all genes (ALL), as well as for the investigated neurotransmission, chemokine, and PI3K-AKT signaling pathways. Here, AKT1 is linked to acute lymphoblastic leukemia.