TNF and periodontal disorder: They have the capacity to take electrons from other atoms and molecules, causing a release of proinflammatory cytokines such as interleukin-2, 6 and 8 (IL-2, IL-6 and IL-8), interferon-β and tumor necrosis factor α (TNF-α), which play an extremely relevant role in the pathogenesis of periodontal disease [16,17].