In previous studies, ADAM8 in particular was described in tumor cells and functional analyses revealed a tumor-promoting effect of ADAM8 in pancreatic cancer cells [4], so that inhibition of ADAM8 in pancreatic cancer (KPC) mice using a cyclic ADAM8 inhibiting peptide (BK-1361) leads to prolonged survival and improved metrics of pathological parameters (metastasis formation, invasion of tumor cells, acinar structures). Here, ADAM8 is linked to familial pancreatic carcinoma.