ROC curve analysis showed that APACHE II (AUC: 0.832 P < .001; 0.755–0.908) cut-off value of ≥24.5 a sensitivity of 79.7%, and a specificity of 84.6%, SCUBE-1 (AUC: 0.813, P < 0.001; CI: 0.747–0.879) a cut-off value of ≥4.73 a sensitivity of 81.3%, and a specificity of 75.6%, SOFA (AUC: 0.784, P < .001; 0.712–0.855) cut-off value of ≥6.50 a sensitivity of 64.1%, and a specificity of 74.6%, CRP (AUC: 0.598, P = .028; 0.511–0.686) cut of value of ≥29.6 a sensitivity of 59.4%, and a specificity of 57.7%, could predict increased risk of 28-day mortality in sepsis patients (Fig. 2). This evidence concerns the gene CRP and Sepsis.