MAPT and Alzheimer disease: Over time, the symptoms become more severe, eventually leading to a loss of independence, requiring 24-hour care, and multiple complications such as malnutrition, bedsores, deep vein thrombosis, and infections, however, these complications are the direct cause of death in AD patients.[3] The main pathological changes of AD were hyperphosphorylated Tau agglutination into neurofibrillary tangles,[4] amyloid-βdeposition into senile plaques,[5] and neuronal apoptosis.