TF and neoplasm: TNFAIP3/A20 participates in not only the endothelial cell stress response, but also the inflammatory response,[14,20,42] which may affect the expression of CA19-9.[29] Woei-A-Jin et al proved that the binding of CA19-9 to apomucins correlated with microparticle-associated tissue factor (TF) activity.[43] TF expressed by tumor cells triggers the formation of thrombin, which leads to both coagulation and platelet activation,[44] which may then result in an increase in D-dimers.