TNFAIP3 and neoplasm: Kang et al demonstrated that TNFAIP3/A20 plays a role in maintaining mitochondrial function.[36] In contrast, Akbari et al demonstrated that intact mitochondrial function positively correlated with tumor differentiation.[37] From these two studies, we may conclude that TNFAIP3/A20 correlates with the differentiation grade of tumors through maintaining mitochondrial function.