As a cytoplasmic zinc-finger protein, TNFAIP3/A20 is reported to be expressed in a variety of human cells, such as T and B lymphocytes, and regulate the dynamic immune response by negatively mediating transcription factor NF-κβ activities and proinflammatory gene expressions.[13,38–41] ENOL-specific TH17 cells have been found to have specific anti-cancer effector functions in pancreatic cancer patients.[25]. This evidence concerns the gene ZNF146 and cancer.