Previous studies have shown that plasma CA19-9 and D-dimer levels correlated with poor prognosis.[7,11,12] TNFAIP3/A20 was found to be a prognostic factor for human cholangiocarcinoma.[45] Multivariate COX analyses showed that TNM stage (P = .007), tumor differentiation grade (P < .001), CA19-9 (P = .005), D-dimer (P = .005), and TNFAIP3/A20 (P < .001) were independent prognostic markers in patients with PDAC, suggesting their usefulness in evaluating the prognosis and progression of PDAC. Here, TNFAIP3 is linked to cholangiocarcinoma.