SRY and disorder of sexual differentiation: In 1990, Sinclair et al suggested that the SRY gene located on chromosome Y (Yp11.32) could be a candidate for the elusive testis-determining gene.[1] Previous studies have indicated that deletion, mutation, translocation, and inversion duplication of the SRY gene may lead to DSD.[2] A 46, XX testicular disorder of sex development, is a human sex chromosomal aberration characterized by the inconsistency between chromosome and gonad, including 46, XX (SRY positive) and 46, XX (SRY negative).