PROS1 and myeloproliferative disorder: In noncirrhotic patients, aPVTs is a relatively rare disease and commonly caused by myeloproliferative diseases, congenital coagulopathies, hypercoagulable states (insufficiency of antithrombin III, protein C, protein S, etc), or oral contraceptives use.[1,11] Severe aPVTs leads to intestinal ischemia or infarction with perforation and peritonitis, which is the most troubling immediate complications.