Abbreviations: BUN = blood urea nitrogen, Ca = calcium, CI = confidence interval, CKD-MBD = chronic kidney disease-mineral and bone disorder, MD = mean difference, P = phosphorus, PTH = parathyroid hormone, RBD = renal bone disease, RCT = randomized controlled trials, RR = risk ratio, SCr = serum creatinine, TCM = traditional Chinese medicine, TKSB = tonifying kidney and strengthen bone, WM = western medicine. The gene discussed is PTH; the disease is chronic kidney disease.