At this time, the increased PTH will mobilize a large amount of bone calcium into the blood to maintain the balance of Ca and P, but it will cause bone calcium loss in bone tissue, leading to osteoporosis, fractures, bone pain, and other bone diseases, which is the so-called CKD-MBD.[7] These diseases have severely affected the quality of the patients’ life and shortened their survival time. Here, PTH is linked to Marchiafava-Bignami disease.