MAPT and Alzheimer disease: To examine whether smoking was associated with changes in cognitive performance (MMSE, FAQ and RAVLT total score), neuroimaging markers (HpVR, EVR and FDG SUVRs) and CSF AD pathologies (CSF Aβ42, t-tau and p-tau levels), we fitted several linear mixed models for each outcome (Tables 2–4 and Figures 1–3).