ACE2 and COVID-19: Following the uptake of COVID-19 by patients with DM, the virus invades the respiratory epithelium and other target cells by binding to cell surface angiotensin-converting enzyme 2, and as a result of the impairment of early recruitment and function of neutrophils and macrophages in patients with DM, the delay in the initiation of adaptive immunity and dysregulation of the cytokine response may lead to the initiation of the cytokine storm, which is associated with the symptomatic state and death among patients with DM.