Of those, 403 (8.8%) individuals were removed as they were considered to be experiencing acute or recent HIV infection, 1066 (23.2%) for having no information on the stage of HIV infection at diagnosis, and 1869 (40.7%) were removed for not meeting the other eligibility criteria (1751 [38.1%] for having only one value for CD4, 117 [2.5%] for having missing information on CD4 and viral load, and one [0.02%] for having a CD4 out of range) (eTable 1 in S1 File). The gene discussed is CD4; the disease is HIV infectious disease.