FLT3 and acute myeloid leukemia: Sorafenib is a multi-targeted small molecule inhibitor of RAF kinase, VEGFR-2, c-KIT, and FLT3, with activity of down-regulation of the MAPK pathway, Mcl-1 (Myeloid cell leukemia-1), and growth inhibition of AML cells with FLT3-ITD mutations [18-20].