In 2018, Wu et al. found that the activation of TLR4/myeloid differentiation factor (MyD) 88 signaling significantly enhanced the migratory and invasive abilities of breast cancer cells and that the expression of TLR4/MyD88 was significantly positively correlated with breast cancer cell metastasis (Wu et al. 2018a). This evidence concerns the gene MYD88 and breast carcinoma.