VEGFA and diabetic retinopathy: One systematic review reported that both anti-VEGF therapy and laser photocoagulation improved vision-related quality of life for diabetic retinopathy, but anti-VEGF therapy resulted in a greater improvement (moderate-quality evidence).25 Likewise, 3 reviews26,27,28 using identical primary studies found that anti-VEGF therapy, compared with a sham treatment, was associated with improvement in vision-related quality of life in people with macular edema secondary to central retinal vein occlusion (high-quality evidence in 1 review27 and moderate-quality evidence in another review26).