VEGFA and age-related macular degeneration: Projections from 2015 suggested that in 2020, 127.7 million people will have moderate or severe vision impairment because of uncorrected refractive error, 57.1 million because of cataract, 8.8 million because of AMD, and 3.2 million because of diabetic retinopathy.83 Three interventions (cataract surgery, corrective lenses, and anti-VEGF therapy) provide opportunities to improve the quality of life of more than 150 million individuals globally.