IGHE and asthma: The predominant etiologic agents, including the species of Aspergillus, Alternaria, Cladosporium, Penicillium, and Fusarium were also identified in FFPE tissue from this patient, which could cause asthma in this patient for up to 20 years since these fungi were speculated colonizing the respiratory tract and triggering IgE-mediated allergic reactions [57, 58].