While this analysis confirms the dominance of morphological changes associated with the VCP mutation, as further visualised in the scatter plots (Figure 1D–F), it indicates that SOD1‐ and VCP‐mutant cells together exhibit subtle and consistent morphological characteristics likely to reflect common ALS attributes and that are captured by the aforementioned 800 measurements (Figure 1G,H). This evidence concerns the gene VCP and amyotrophic lateral sclerosis.