fermentum MCC2759 and MCC2760 exhibited beneficial effects in HFD and type 2 diabetic models by improving glucose and lipid profile, reduction of pro-inflammatory cytokines in liver, intestine, MAT, and muscle tissue, and improving the intestinal barrier function and expression of GLUT4, GLP1, and adiponectin. Lact. This evidence concerns the gene SLC2A4 and type 2 diabetes mellitus.