An OVV with the tk gene deleted but expressing IL-24 (VV-IL-24) efficiently infected A549 human lung cancer xenografts, promoting caspase-dependent apoptosis with decreased STAT3 expression.64 Interleukin-24 (IL-24)/mda-7 is a member of the IL-10 family of cytokines that signals through two receptors (IL-20R1/IL-20R2 and IL-22R1/IL-20R2). This evidence concerns the gene IL20RB and lung cancer.