CYP3A4 and steatosis: Therefore, expression changes of AHR, NR1I3 (CAR) and NR1I2 (PXR), their target genes CYP1A1, CYP1A2, CYP2B6 and CYP3A4, as well as some steatosis-related genes (ACOX1, ACOX2, CD36, FASN, MLXIPL, SCD and SREPF1) were investigated to examine if gene expression changes may be responsible for the potentiation of the steatotic effect by FDO.