Smith Smith MR MR Natural history of rising serum prostate-specific antigen in men with castrate nonmetastatic prostate cancer Natural history of rising serum prostate-specific antigen in men with castrate nonmetastatic prostate cancer J Clin Oncol J Clin Oncol 2005 2005 23 23 2918 2918 2925 2925 10.1200/JCO.2005.01.529 10.1200/JCO.2005.01.529 15860850 15860850. The gene discussed is KLK3; the disease is Familial prostate cancer.