The protein encoded by CKS1B binds SKP2, increasing the activity of the E3 ubiquitin ligase Skp1–Cullin-1–Skp2 that degrades p27 (50), a pathway shown to be involved in regulating β-cell mass and function with implications for T2D development (49). The gene discussed is CUL1; the disease is type 2 diabetes mellitus.