Prominent examples are RPS14/uS11, RPSA/uS2 and RPL38/eL38 genes with mutations associated with 5q- myelodysplastic syndrome (20), isolated congenital asplenia (21) and skeletal defects during embryogenesis, including perturbations in the formation of the axial skeleton (22). This evidence concerns the gene RPS14 and familial isolated congenital asplenia.