Treatment-related AEs could be attributed to Ad5-yCD/mutTKSR39rep-hIL-12 (chills, fatigue, flu-like symptoms, malaise, and increased serum alanine aminotransferase/serum glutamic-pyruvic transaminase [ALT/SGPT] and aspartate transferase/serum glutamic oxaloacetic transaminase [AST/SGOT]) or the 5-FC prodrug therapy (anemia, diarrhea, nausea, vomiting, leukopenia, lymphopenia, and thrombocytopenia) (Table S1). Here, GOT1 is linked to lymphopenia.