NK cell lectin-like receptor K1 (KLRK1 or NKG2D), encoded by Klrk1 gene, is an activating receptor on natural killer (NK) and T cells to lyse M. tuberculosis-infected monocytes and alveolar macrophages, and a promising target for regulating CD8+ T cell-mediated protection against TB [37]. The gene discussed is CD8A; the disease is tuberculosis.