HSPG2 and tuberculosis: As shown in Figure 8, we found that 21 DE genes were significantly downregulated in TB-infected mice but were distinctly upregulated after treatment with NBXH-H, including GF, GPCR, RTK, M-ras, Cam, AC, PLC, SLP-76, PKC, RapGAP, Ras, ID1, TSP1, Ral, Rac, Integrin, p120, ERK, MEK3,6, PI3K, and Akt. Additionally, seven pathways were downregulated in TB-infected mice.