In further binary logistic regression analysis for males and females, diabetes duration (OR = 1.119, 95% CI 1.079–1.161), HbA1c (OR = 1.254, 95% CI 1.132–1.390), and LH (OR = 1.086, 95% CI 1.024–1.152) showed being independent risk factors for male diabetic retinopathy patients, after controlling for age, smoking, drinking, systolic BP, BMI, HbA1c, TG, TC, FSH, T, DHEAS, and SHBG (Figure 1). The gene discussed is SHBG; the disease is diabetes mellitus.