Ongoing RCTs ECOG ACRIN (NCT04181060) and HCRN (NCT03909334) are investigating first-line treatment strategies of osimertinib combined with bevacizumab or ramucirumab in patients with EGFR-mutant advanced or metastatic NSCLC and may produce important data in the future. Here, EGFR is linked to non-small cell lung carcinoma.