In further research, a recent study by Swain et al. [184, 185] showed that when mechanically stimulating pancreatic acinar cells, calcium ion permeation through an activated piezo1 protein channel is the first step in stress-induced pancreatitis, and piezo1-induced TRPV4 channel opening is the main factor leading to pancreatitis. This evidence concerns the gene PIEZO1 and pancreatitis.