In line with this study, 43 genes (including CLIP4) were downregulated in ovarian cancer tumor samples and reactivated after treatment with 5-Aza-2'-deoxycytidine (5-aza-dC); CLIP4, GULP1, BAMBI, NT5E, and TGFB2 showed a pattern of cancer-specific methylation (Maldonado et al., 2018). This evidence concerns the gene NT5E and cancer.