In clear cell renal cell carcinoma (ccRCC), CLIP4 mutations are three-fold higher in patients with aggressive tumors than in those without aggressive ccRCC, and high expression levels of MOCOS, BAIAP2L1, DDX11, and CLIP4 are markedly associated with poor OS (Park et al., 2020). Here, MOCOS is linked to nonpapillary renal cell carcinoma.