The first studies with plasma-derived EVs focused on the analysis of EGFR in lung cancer and glioblastoma (Figueroa et al., 2017; Krug et al., 2017; Castellanos-Rizaldos et al., 2018) and KRAS in pancreatic cancer (Allenson et al., 2017; Yang et al., 2017). This evidence concerns the gene EGFR and glioblastoma.