Further, several other genes such as LDH-B described as hypermethylated in prostate cancer; ID4, potential tumor suppressor gene in prostate cancer; ANXA2 indicator of poor prognosis, recurrence, metastasis, high Gleason; PSGR, potential serum biomarker of prostate cancer; ID2, a p53 independent anti-apoptotic function in prostate cancer cells was found to be down regulated; and MEIS2, which act as putative tumor suppressor genes in prostate cancer; NPY, differentially expressed and up-regulated in 60% of “non-aggressive” tumors. This evidence concerns the gene ANXA2 and Familial prostate cancer.