The HLA (human leukocyte antigen), LDHB (Lactate Dehydrogenase B), lipocortin I (Annexin A1, ANAX1), ANAX2 (Annexin A2), MEIS1 (Meis Homeobox 1), developmental genes such as SLC40A1 (Solute Carrier Family 40 Member 1), FOXQ1 (Forkhead Box Q1), DNA binding protein SOX9 [SRY- Sex Determining Region Y)-Box 9], ID2 (Inhibitor Of DNA Binding 2), immune system and developmental biology related gene, CEBPD (CCAAT Enhancer Binding Protein Delta), and LDHB (Lactate Dehydrogenase B) previously described as hypermethylated in prostate cancer were down-regulated in old prostate cancer patients. The gene discussed is ANXA2; the disease is Familial prostate cancer.